Effects of Estrogen Treatment During the Embryogenic Period on Chick Antibody Production
| Autor: | Yasuhiro Kondo, Chitose Goto, Asaki Abe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | The Journal of Poultry Science, Vol 41, Iss 2, Pp 85-93 (2004) |
| Druh dokumentu: | article |
| ISSN: | 1346-7395 1349-0486 |
| DOI: | 10.2141/jpsa.41.85 |
| Popis: | Antibody production against a T cell-dependent antigen (goat red blood cell) and a T cell-independent antigen (killed Brucella abortus) was examined in chicks treated with estrogen in which eggs were dipped into ethyl alcohol solution containing β-estradiol. Relative weights (organ weights/body weight) of the primary lymphoid organs of chicks were also determined. Secondary antibody production against goat red blood cells (GRBC) was significantly increased by treating chick embryos with high doses of estrogen (1.0% solution) on the 4th day of embryogenesis. Primary and secondary antibody responses against killed Brucella abortus (BA) were dose-dependently increased with estrogen treatment on the 4th day of embryogenesis. In contrast, primary and secondary responses against BA of chicks treated with estrogen on the 14th day of embryogenesis were significantly suppressed. Thymus weight significantly increased in chicks treated with estrogen on the 4th day of embryogenesis. The rate of CD4-positive cells in the chick thymocytes significantly increased with estrogen treatment on the 4th day of embryogenesis. On the other hand, the weight of the bursa of Fabricius significantly decreased when treating chick embryos with high doses of estrogen (1.0%) on the 14th day of embryogenesis. Results from the present study indicated that estrogen treated at different stages of embryogenesis exerts discrete effects on B cell differentiation in the bursa and helper T cell differentiation in the thymus of chick embryos. |
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