Modeling of Red Blood Cells in Capillary Flow Using Fluid–Structure Interaction and Gas Diffusion

Autor:	Ling An, Fenglong Ji, Yueming Yin, Yi Liu, Chichun Zhou
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	diffusion capacity cell deformation cell clustering capacity flow Cytology QH573-671
Zdroj:	Cells, Vol 11, Iss 24, p 3987 (2022)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells11243987
Popis:	Red blood cell (RBC) distribution, RBC shape, and flow rate have all been shown to have an effect on the pulmonary diffusing capacity. Through this study, a gas diffusion model and the immersed finite element method were used to simulate the gas diffusion into deformable RBCs running in capillaries. It has been discovered that when RBCs are deformed, the CO flux across the membrane becomes nonuniform, resulting in a reduced capacity for diffusion. Additionally, when compared to RBCs that were dispersed evenly, our simulation showed that clustered RBCs had a significantly lower diffusion capability.
Databáze:	Directory of Open Access Journals
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