Left ventricular reverse remodeling after aortic valve replacement or repair in bicuspid aortic valve with moderate or greater aortic regurgitationCentral MessagePerspective

Autor: Jonathan D. Kochav, MD, Hiroo Takayama, MD, PhD, Andrew Goldstone, MD, PhD, David Kalfa, MD, PhD, Emile Bacha, MD, Marlon Rosenbaum, MD, Matthew J. Lewis, MD, MPH
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JTCVS Open, Vol 19, Iss , Pp 47-60 (2024)
Druh dokumentu: article
ISSN: 2666-2736
DOI: 10.1016/j.xjon.2024.03.006
Popis: Objective: Bicuspid aortic valve (AV) patients with aortic regurgitation (AR) differ from tricuspid AV patients given younger age, greater left ventricle (LV) compliance, and more prevalent aortic stenosis (AS). Bicuspid AV-specific data to guide timing of AV replacement or repair are lacking. Methods: Adults with bicuspid AV and moderate or greater AR who underwent aortic valve replacement or repair at our center were studied. The presurgical echocardiogram, and echocardiograms within 3 years postoperatively were evaluated for LV geometry/function, and AV function. Semiquantitative AS/AR assessment was performed in all patients with adequate imaging. Results: One hundred thirty-five patients (85% men, aged 44.5 ± 15.9 years) were studied (63% pure AR, 37% mixed AS/AR). Following aortic valve replacement or repair, change in LV end-diastolic dimension and change in LV end-diastolic volume were associated with preoperative LV end-diastolic dimension (β = 0.62 Δcm/cm; 95% CI, 0.43-0.73 Δcm/cm; P
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