CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Autor: Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mBio, Vol 12, Iss 5 (2021)
Druh dokumentu: article
ISSN: 2150-7511
DOI: 10.1128/mBio.01163-21
Popis: Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes formation of a complex with the cellular protein TopBP1 in vitroin vivo
Databáze: Directory of Open Access Journals