The proteome signature of cord blood plasma with high hematopoietic stem and progenitor cell count

Autor: Anders K. Nilsson, Halfdan Rydbeck, Annika Thorsell, Sofia Frändberg, Helena Barreto Henriksson, Camilla Hesse, Gunnel Hellgren, Pia Lundgren, Ann Hellström
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Stem Cell Research, Vol 61, Iss , Pp 102752- (2022)
Druh dokumentu: article
ISSN: 1873-5061
DOI: 10.1016/j.scr.2022.102752
Popis: Hematopoietic stem and progenitor cells (HSPC) from umbilical cord blood (UCB) are used for transplantation to treat blood disorders. Methods to estimate the HSPC count in umbilical cord blood, and thereby identify high-value blood units, are time-consuming and costly. Recent studies indicate that the UCB plasma protein composition relates to the HSPC count. We compared the plasma proteome of UCB with high vs low HSPC cell count (>115 × 106 vs
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