Survival Study of Triple-Negative and Non–Triple-Negative Breast Cancer in a Brazilian Cohort

Autor: Homero Gonçalves, Maximiliano Ribeiro Guerra, Jane Rocha Duarte Cintra, Vívian Assis Fayer, Igor Vilela Brum, Maria Teresa Bustamante Teixeira
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Clinical Medicine Insights: Oncology, Vol 12 (2018)
Druh dokumentu: article
ISSN: 1179-5549
11795549
DOI: 10.1177/1179554918790563
Popis: Objective: To analyze the clinical, pathological, and sociodemographic aspects between triple-negative breast cancer (TNBC) and non-TNBC in a Brazilian cohort and identify potential prognostic factors. Methods: This hospital-based retrospective cohort study included 447 women with breast cancer treated at referral centers in Southeastern Brazil. Overall and disease-free survival were compared; prognostic factors were evaluated. Results: Triple-negative breast cancer corresponded to 19.5% of breast cancer diagnosis and was more prevalent among nonwhite and less educated women. The patients with TNBC tended to present with stage III cancer, high p53 expression, lymphocytic infiltration, and multifocality and treated with radical surgery and chemotherapy. The 5-year overall and disease-free survival were 62.1% and 57.5% for TNBC and 80.8% and 75.3% for non-TNBC, respectively ( P
Databáze: Directory of Open Access Journals
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