Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

Autor: Yiran Lang, Rongyu Tang, Yafei Liu, Pengcheng Xi, Honghao Liu, Zhenzhen Quan, Da Song, Xiaodong Lv, Qiang Huang, Jiping He
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biosensors, Vol 11, Iss 12, p 503 (2021)
Druh dokumentu: article
ISSN: 2079-6374
DOI: 10.3390/bios11120503
Popis: Neural interfaces typically focus on one or two sites in the motoneuron system simultaneously due to the limitation of the recording technique, which restricts the scope of observation and discovery of this system. Herein, we built a system with various electrodes capable of recording a large spectrum of electrophysiological signals from the cortex, spinal cord, peripheral nerves, and muscles of freely moving animals. The system integrates adjustable microarrays, floating microarrays, and microwires to a commercial connector and cuff electrode on a wireless transmitter. To illustrate the versatility of the system, we investigated its performance for the behavior of rodents during tethered treadmill walking, untethered wheel running, and open field exploration. The results indicate that the system is stable and applicable for multiple behavior conditions and can provide data to support previously inaccessible research of neural injury, rehabilitation, brain-inspired computing, and fundamental neuroscience.
Databáze: Directory of Open Access Journals