Senescence in the aging process [version 1; referees: 3 approved]
| Autor: | Richard GA Faragher, Anne McArdle, Alison Willows, Elizabeth L. Ostler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Aging
Cancer Therapeutics Cardiovascular Pharmacology Cardiovascular Physiology/Circulation Cell Growth & Division Cell Signaling Cellular Death & Stress Responses Control of Gene Expression Developmental Molecular Mechanisms Endocrine & Metabolic Pharmacology Immunopharmacology & Hematologic Pharmacology Innate Immunity Membranes & Sorting Morphogenesis & Cell Biology Musculoskeletal Pharmacology Neurobiology of Disease & Regeneration Neuronal & Glial Cell Biology Neuropharmacology & Psychopharmacology Nuclear Structure & Function Renal Pharmacology Medicine Science |
| Zdroj: | F1000Research, Vol 6 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.10903.1 |
| Popis: | The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts. Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms by which the deleterious effects of senescent cells can be ameliorated. |
| Databáze: | Directory of Open Access Journals |
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