Discovery of 'Molecular Switches' within a Series of mGlu5 Allosteric Ligands Driven by a 'Magic Methyl' Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype

Autor: Lisa Barbaro, Alice L. Rodriguez, Ashlyn N. Blevins, Jonathan W. Dickerson, Natasha Billard, Olivier Boutaud, Jerri L. Rook, Colleen M. Niswender, P.Jeffrey Conn, Darren W. Engers, Craig W. Lindsley
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 21-30 (2021)
Druh dokumentu: article
ISSN: 2694-2437
DOI: 10.1021/acsbiomedchemau.1c00024
Databáze: Directory of Open Access Journals