SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis

Autor: J. Daniel Kelly, Tristan Curteis, Aaditya Rawal, Molly Murton, Laura J. Clark, Zarena Jafry, Rikisha Shah-Gupta, Mark Berry, Aprille Espinueva, Linda Chen, Mazin Abdelghany, Daniel A. Sweeney, Jennifer K. Quint
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: European Respiratory Review, Vol 32, Iss 169 (2023)
Druh dokumentu: article
ISSN: 0905-9180
1600-0617
16000617
DOI: 10.1183/16000617.0254-2022
Popis: Background Many individuals hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience post-acute sequelae of SARS-CoV-2 infection (PASC), sometimes referred to as “long COVID”. Our objective was to conduct a systematic literature review and meta-analysis to identify PASC-associated symptoms in previously hospitalised patients and determine the frequency and temporal nature of PASC. Methods Searches of MEDLINE, Embase, Cochrane Library (2019–2021), World Health Organization International Clinical Trials Registry Platform and reference lists were performed from November to December 2021. Articles were assessed by two reviewers against eligibility criteria and a risk of bias tool. Symptom data were synthesised by random effects meta-analyses. Results Of 6942 records, 52 studies with at least 100 patients were analysed; ∼70% were Europe-based studies. Most data were from the first wave of the pandemic. PASC symptoms were analysed from 28 days after hospital discharge. At 1–4 months post-acute SARS-CoV-2 infection, the most frequent individual symptoms were fatigue (29.3% (95% CI 20.1–40.6%)) and dyspnoea (19.6% (95% CI 12.8–28.7%)). Many patients experienced at least one symptom at 4–8 months (73.1% (95% CI 44.2–90.3%)) and 8–12 months (75.0% (95% CI 56.4–87.4%)). Conclusions A wide spectrum of persistent PASC-associated symptoms were reported over the 1-year follow-up period in a significant proportion of participants. Further research is needed to better define PASC duration and determine whether factors such as disease severity, vaccination and treatments have an impact on PASC.
Databáze: Directory of Open Access Journals
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