| Autor: |
V. M. Dudnyk, O. V. Kutsak |
| Jazyk: |
English<br />Spanish; Castilian<br />Polish<br />Russian<br />Ukrainian |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Journal of Education, Health and Sport, Vol 7, Iss 5, Pp 934-943 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2391-8306 |
| DOI: |
10.5281/zenodo.1206402 |
| Popis: |
Today, the mechanism of development of bronchial asthma (BA) is interpreted from the molecular-genetic point of view, taking into account the polymorphism of genes that affect the formation and clinical manifestations of it. Studying the genetic aspects of bronchial asthma in children is aimed at studying various associations of polymorphisms of genes of interleukin ligands and their receptors. The aim - to evaluate the prevalence of genotypes and alleles for the gene polymorphism lle50Val IL4RA in patients with asthma and healthy school children Vinnitsa region. Materials and methods. We examined 75 children of school age, patients with atopic bronchial asthma and 25 practically healthy children aged 6 to 18 years living in Vinnitsa region. The genotyping of IL4RA, SNP polymorphism lle50Val was carried out using a polymerase chain reaction (PCR). The odds ratio was calculated to determine the risk of developing asthma in carriers of various alleles and genotypes of the IL4RA gene. Results and discussion. Homozygous genotype A / A Vinnichiny among school children suffering from asthma occurs in 4.34 times (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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