Association of Src with Nottingham prognostic index in breast cancer: Implications for breast cancer prognostication
| Autor: | Primariadewi Rustamadji, Elvan Wiyarta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Nature and Science of Medicine, Vol 7, Iss 2, Pp 90-94 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2589-627X 2589-6288 |
| DOI: | 10.4103/jnsm.jnsm_192_23 |
| Popis: | Background: Breast cancer affects one out of every eight women worldwide. Although the Nottingham Prognostic Index (NPI) is an important tool for forecasting, its accuracy remains a matter of contention. The Src protein, which has been linked to cancer proliferation and metastasis, may provide improved prognostic information. Aim: The aim of the study was to investigate the relationship between Src expression levels and the NPI in breast cancer patients. Methods: From January 2019 to December 2022, breast cancer samples were collected retrospectively. Immunohistochemistry was used to quantify Src expression, followed by digital image analysis using ImageJ software. To assure consistency, expression levels were standardized to a control protein. The samples were then stratified according to their NPI scores, and t-test was used to determine the relationship between Src expression and NPI. P |
| Databáze: | Directory of Open Access Journals |
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