Serum interleukin 38 (IL-38) as a new potential biomarker of pediatric asthma

Autor: Asmaa Kamal, Christine W. S. Basanti, Mahmoud A. Kaushty, Azza K. Abdelmegeid
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Egyptian Journal of Bronchology, Vol 16, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 1687-8426
2314-8551
DOI: 10.1186/s43168-022-00139-5
Popis: Abstract Background Bronchial asthma is considered the most prevalent chronic respiratory disease worldwide and is one of the main causes of hospitalization in the pediatric population. Serum interleukin 38 (IL-38) levels are elevated in several inflammatory and autoimmune diseases. However, its exact role in the pathogenesis of these diseases is unclear. Objectives To investigate the role of IL-38 as a potential biomarker in pediatric patients with bronchial asthma. Methods Serum IL-38 levels were measured in 73 pediatric patients with bronchial asthma (34 atopic and 39 non-atopic) and 30 age- and sex-matched healthy control subjects using enzyme-linked immunosorbent assay. Results Serum IL-38 levels were significantly higher in patients with bronchial asthma compared to the control group (p < 0.001). A significant negative correlation was found between serum IL-38 levels and both relative and absolute eosinophilic counts in the atopic group (R = −0.575, p < 0.001 and R = −0.474, p = 0.005, respectively). Conclusion IL-38 could be a useful prognostic and therapeutic biomarker of atopic asthma in pediatric patients.
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