Human apolipoprotein A-I prevents atherosclerosis associated with apolipoprotein[a] in transgenic mice.
| Autor: | A C Liu, R M Lawn, J G Verstuyft, E M Rubin |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Journal of Lipid Research, Vol 35, Iss 12, Pp 2263-2267 (1994) |
| Druh dokumentu: | article |
| ISSN: | 0022-2275 19499035 |
| DOI: | 10.1016/S0022-2275(20)39932-6 |
| Popis: | Elevated levels of apolipoprotein[a] (apo[a]) and apolipoprotein A-I (apoA-I) are associated, respectively, with increased and decreased atherosclerosis risk, in both humans and transgenic mice. To investigate the interactions of these two important lipid-associated proteins, we assessed the effect of expression of human apoA-I and apo[a] transgenes, both singularly and together, on murine atherogenesis. Mice expressing the apo[a] transgene have a lipoprotein profile similar to nontransgenic controls, yet have significantly increased susceptibility to diet-induced atherosclerosis. Compared to mice expressing only the apo[a] transgene, mice expressing both apo[a] and apoA-I transgenes have twofold greater high density lipoprotein (HDL) concentrations and approximately a 20-fold decrease in development of early atherosclerotic lesions. The finding of decreased atherosclerosis in the setting of elevated apo[a] and apoA-I suggests that elevations of apoA-I and HDL have a dominant effect in reducing atherosclerosis susceptibility in various settings, including those not associated with alterations of plasma lipids. |
| Databáze: | Directory of Open Access Journals |
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