The relative impact of components of high residual risk on the long-term prognosis after AMI

Autor: Gian Francesco Mureddu, Paola D'Errigo, Stefano Rosato, Pompilio Faggiano, Gabriella Badoni, Roberto Ceravolo, Vito Altamura, Mirko Di Martino, Marco Ambrosetti, Fabrizio Oliva, Paola Ciccarelli, Giovanni Baglio
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 22, Iss , Pp 200310- (2024)
Druh dokumentu: article
ISSN: 2772-4875
DOI: 10.1016/j.ijcrp.2024.200310
Popis: Background: The reduction in long-term mortality after acute myocardial infarction (AMI) is less pronounced than that of in-hospital mortality among patients with AMI complicated by heart failure (HF) and/or in those with a high residual thrombotic risk (HTR). Aim: To investigate the relative prognostic significance of HTR and HF in AMI survivors. Methods: This retrospective cohort study enrolled patients admitted for AMI in 2014–2015 in all Italian hospitals. HTR was defined as at least one of the following conditions: previous AMI, ischemic stroke or other vascular disease, type 2 diabetes, renal failure. Patients were classified into four categories: uncomplicated AMI; AMI with HTR; AMI with HF and AMI with both HTR and HF (HTR + HF). Cox proportional hazard model was used to evaluate the impact of HTR, HF and HTR + HF on the 5-year prognosis. A time-varying coefficient analysis was performed to estimate the 5-year trend of HR for major averse cardiac and cerebrovascular events (MACCE). Results: a total of 174.869 AMI events were identified. The adjusted 5-year HR for MACCE was 1.74 (p
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