ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review

Autor: Taiki Okumura, Shohei Takayama, Shin‐ichi Nishio, Takahiro Miyakoshi, Takuro Noguchi, Takashi Kobayashi, Toshirou Fukushima, Nodoka Sekiguchi, Toshiaki Otsuki, Mitsuhisa Komatsu, Tomonobu Koizumi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Thoracic Cancer, Vol 10, Iss 7, Pp 1648-1653 (2019)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.13099
Popis: A 32‐year‐old woman was referred to our hospital because of severe psychosis and was found to have an ectopic ACTH‐producing thymic neuroendocrine tumor. Laboratory data revealed an elevated serum cortisol and plasma ACTH level, hypokalemia, and metabolic alkalosis. Chest computed tomography (CT) revealed an anterior mediastinal mass and multiple pulmonary nodules. As the patient was unable to communicate because of her consciousness disturbance, she was managed with artificial ventilation and deep sedation. Metyrapone and potassium supplementation were administered, and steroid psychosis gradually improved. Thoracic surgery was performed and the histopathological diagnosis was thymic neuroendocrine tumor with positive anti‐ACTH immunohistochemical staining. Here we present details of the case and review the literature.
Databáze: Directory of Open Access Journals
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