Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Autor: Hassan Ghasemnejad, Davood Azarifar
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Zdroj: Molecules, Vol 8, Iss 8, Pp 642-648 (2003)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/80800642
Popis: Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.
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