Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis
| Autor: | Vincenza Conteduca, Sheng-Yu Ku, Luisa Fernandez, Angel Dago-Rodriquez, Jerry Lee, Adam Jendrisak, Megan Slade, Cole Gilbertson, Jyothi Manohar, Michael Sigouros, Yipeng Wang, Ryan Dittamore, Rick Wenstrup, Juan Miguel Mosquera, Joseph D. Schonhoft, Himisha Beltran |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2397-768X 49833146 |
| DOI: | 10.1038/s41698-021-00211-1 |
| Popis: | Abstract Neuroendocrine prostate cancer is an aggressive variant of prostate cancer that may arise de novo or develop from pre-existing prostate adenocarcinoma as a mechanism of treatment resistance. The combined loss of tumor suppressors RB1, TP53, and PTEN are frequent in NEPC but also present in a subset of prostate adenocarcinomas. Most clinical and preclinical studies support a trans-differentiation process, whereby NEPC arises clonally from a prostate adenocarcinoma precursor during the course of treatment resistance. Here we highlight a case of NEPC with significant intra-patient heterogeneity observed across metastases. We further demonstrate how single-cell genomic analysis of circulating tumor cells combined with a phenotypic evaluation of cellular diversity can be considered as a window into tumor heterogeneity in patients with advanced prostate cancer. |
| Databáze: | Directory of Open Access Journals |
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