SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS
| Autor: | D. S. Esmedlyaeva, O. T. Titarenko, M. V. Pavlova, M. E. Dyakova, T. L. Perova |
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| Jazyk: | ruština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Туберкулез и болезни лёгких, Vol 0, Iss 8, Pp 38-42 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2075-1230 2542-1506 |
| DOI: | 10.21292/2075-1230-2015-0-8-38-42 |
| Popis: | New untreated infiltrate pulmonary tuberculosis patients commonly demonstrated the same referent level of MMP-8, MMP-3 and multiple increase of MMP-9 level on the background of diverse changes of inhibiting potential (retaining the reference level of TIMP-1 and reduced α2 -МG). Destructive process is related to unbalanced increase of рro-ММР-1 and ММР-9. At the same time the level of рro-ММР-1 correlates to changes in ROF, activity of proteinases of other classes (serine proteinases) and depends on the dissemination of the disease, while the changes in MMP-9 level are influenced by the massiveness of bacillary excretion. |
| Databáze: | Directory of Open Access Journals |
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