Systems-level reconstruction of kinase phosphosignaling networks regulating endothelial barrier integrity using temporal data

Autor:	Ling Wei, John D. Aitchison, Alexis Kaushansky, Fred D. Mast
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Biology (General) QH301-705.5
Zdroj:	npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-8 (2024)
Druh dokumentu:	article
ISSN:	2056-7189
DOI:	10.1038/s41540-024-00468-9
Popis:	Abstract Phosphosignaling networks control cellular processes. We built kinase-mediated regulatory networks elicited by thrombin stimulation of brain endothelial cells using two computational strategies: Temporal Pathway Synthesizer (TPS), which uses phosphoproteomics data as input, and Temporally REsolved KInase Network Generation (TREKING), which uses kinase inhibitor screens. TPS and TREKING predicted overlapping barrier-regulatory kinases connected with unique network topology. Each strategy effectively describes regulatory signaling networks and is broadly applicable across biological systems.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/192620f19c764938a58fbb761d5e3ba5 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.