Positive and Negative Regulators of Sclerostin Expression

Autor:	Rina Iwamoto, Masanori Koide, Nobuyuki Udagawa, Yasuhiro Kobayashi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	sclerostin Wnt inhibitor bone remodeling osteoclast osteocyte LIF Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 23, Iss 9, p 4895 (2022)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms23094895
Popis:	Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negative regulator of bone formation. A sclerostin deficiency causes sclerosteosis, which is characterized by an excess bone mass with enhanced bone formation in humans and mice. The expression of sclerostin is positively and negatively regulated by many factors, which also govern bone metabolism. Positive and negative regulators of sclerostin expression and their effects are introduced and discussed herein based on recent and previous findings, including our research.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1918465f3c9d4414b4ecfcc2b57824d3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.