Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues

Autor:	Jacob A. Herring, Weston S. Elison, Jeffery S. Tessem
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	nr4a1 nr4a2 nr4a3 nuclear hormone receptors metabolism fuel utilization proliferation apoptosis Cytology QH573-671
Zdroj:	Cells, Vol 8, Iss 11, p 1373 (2019)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells8111373
Popis:	The Nr4a family of nuclear hormone receptors is composed of three members—Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.
Databáze:	Directory of Open Access Journals
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