COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

Autor: Wayne F. Leung, Samuel Chorlton, John Tyson, Ghada N. Al-Rawahi, Agatha N. Jassem, Natalie Prystajecky, Shazia Masud, Gregory D. Deans, Michael G. Chapman, Yazdan Mirzanejad, Melanie C.M. Murray, Patrick H.P. Wong
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 114, Iss , Pp 178-182 (2022)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2021.10.045
Popis: ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.
Databáze: Directory of Open Access Journals