Differentially methylated regions (DMRs) in PON3 gene between responders and non-responders to a weight loss dietary intervention: a new tool for precision management of obesity
| Autor: | Francisca Salas-Pérez, Amanda Cuevas-Sierra, Marta Cuervo, Leticia Goni, Fermín I. Milagro, J. Alfredo Martínez, José Ignacio Riezu-Boj |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Epigenetics, Vol 17, Iss 1, Pp 81-92 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1559-2294 1559-2308 15592294 |
| DOI: | 10.1080/15592294.2021.1873629 |
| Popis: | Differentially methylated regions (DMR) are genomic regions with different methylation status. The aim of this research was to identify DMRs in subjects with obesity that predict the response to a weight-loss dietary intervention and its association with metabolic variables. Based on the change in body mass index (BMI), 201 subjects with overweight and obesity were categorized in tertiles according to their response to a hypocaloric diet: Responders (R; n = 64) and Non-Responders (NR; n = 63). The R group lost 4.55 ± 0.91 BMI units (kg/m2) and the NR group lost 1.95 ± 0.73 kg/m2 (p |
| Databáze: | Directory of Open Access Journals |
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