| Autor: |
Ahsan Habibul, Chen Yu, Ostrer Harry, Oddoux Carole, Ellis Nathan, Liu Junjian, Rosman Diana, Baddi Lisa, Kaklamani Virginia, Offit Kenneth, Pasche Boris |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
BMC Genetics, Vol 5, Iss 1, p 28 (2004) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2156 |
| Popis: |
Abstract Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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