A 'Proteoglycan Targeting Strategy' for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model

Autor: Caroline Peyrode, François Gouin, Aurélien Vidal, Philippe Auzeloux, Sophie Besse, Marie-Mélanie Dauplat, Serge Askienazy, Dominique Heymann, Jean-Michel Chezal, Françoise Redini, Elisabeth Miot-Noirault
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Sarcoma, Vol 2011 (2011)
Druh dokumentu: article
ISSN: 1357-714X
1369-1643
DOI: 10.1155/2011/691608
Popis: Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. 99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.
Databáze: Directory of Open Access Journals
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