| Autor: |
Yu-Hong Cheng, Qiang Shi, Jia-Quan Shen, Li-Lun Wang, Si-Wei Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Guoji Yanke Zazhi, Vol 15, Iss 7, Pp 1154-1157 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1672-5123 |
| DOI: |
10.3980/j.issn.1672-5123.2015.7.09 |
| Popis: |
AIM: To investigate expressions of matrix metalloproteinase-2(MMP-2)and extracellular matrix metalloproteinase inducer(EMMPRIN)in retinoblastoma(Rb)and the relationships between MMP-2, EMMPRIN and tumor development.METHODS:Immunohistochemical technique was used to detect expressions of MMP-2 and EMMPRIN in 39 cases of paraffin embedded Rb samples. Quantitative analysis of expressions of MMP-2 and EMMPRIN were assessed by measuring the mean gray scale of Rb tissue with LEICA IM50 Color Pathologic Analysis System. The differences of expressions of MMP-2 and EMMPRIN in each clinical and pathological stage were statistically analyzed, and the same step was also undertaken to study the relationship between Rb with MMP-2 positive expression and that with EMMPRIN positive expression.RESULTS: The positive expression rate of MMP-2 was 90%(Gray value: 109.64±14.52; 35/39), and that of EMMPRIN was 85%(Gray value: 108.01±13.60; 33/39). The expressions of MMP-2 and EMMPRIN were significantly higher in tumors of glaucomatous stage(Gray value: 108.21±11.47 and 107.56±14.32)than those in intraocular stage(Gray value: 121.13±11.32 and 119.34±12.66; PPPPPPCONCLUSION: The positive expression levels of MMP-2 and EMMPRIN may correlate with tumor infiltration and metastasis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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