Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Autor:	Xiaoping Zhan, Zhenmin Mao, Sijing Chen, Shaoxiong Chen, Liqun Wang
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Dinitrato de isossorbida/Sistema de liberação transdérmico Formulações transdérmicas/liberação in vitro Formulações transdérmicas/liberação sustentada Membrana de controle/taxa de liberação de fármacos Penetração cutânea/liberação de fármacos Pharmacy and materia medica RS1-441
Zdroj:	Brazilian Journal of Pharmaceutical Sciences, Vol 51, Iss 2, Pp 373-382 (2015)
Druh dokumentu:	article
ISSN:	2175-9790 1984-8250
DOI:	10.1590/S1984-82502015000200015
Popis:	The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the in vitro release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (p> 0.05). Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/18ba520d5ace4aa3a7ac50a9c5283722 Zobrazit plný text záznamu View record in DOAJ