| Autor: |
I. Olarte-Carrillo, C.O. Ramos-Peñafiel, E. Miranda-Peralta, I. Mendoza-Salas, K.A. Nacho-Vargas, J.A. Zamora-Domínguez, E. Mendoza-García, E. Rozen-Fuller, J.J. Kassack-Ipiña, J. Collazo-Jaloma, A. Martínez-Tovar |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Revista Médica del Hospital General de México, Vol 78, Iss 3, Pp 119-123 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
0185-1063 |
| DOI: |
10.1016/j.hgmx.2015.08.001 |
| Popis: |
Background: The minor BCR-ABL (e1;a2) transcript oncogene is the most common genetic alteration in adults with acute lymphoblastic leukaemia (ALL). It is associated with a poor prognosis. Aim: To determine the frequency of minor BCR-ABL (e1;a2) transcript oncogene expression in ALL patients in Mexico. Material and methods: A cohort of 411 patients with de novo ALL were tested for the oncogene using reverse transcription polymerase chain reaction (RT-PCR). Results: The oncogene was found in 14% (n = 57) of the study population. Mean age was 29 years, and 53% were male. Median leucocyte count was 53 × 103 μl. Conclusion: Prevalence of BCR-ABL expression by RT-PCR has not previously been reported in Mexico. Our laboratory found a higher prevalence than that reported in Latin-American series, but lower than that reported for the European population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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