In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma

Autor:	Bas D. Koster, Tamarah D. de Jong, Mari F. C. M. van den Hout, Berbel J. R. Sluijter, Ronald J. C. L. M. Vuylsteke, Barbara G. Molenkamp, Saskia Vosslamber, M. Petrousjka van den Tol, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	gm-csf cpg melanoma dendritic cells sentinel lymph node Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 9, Iss 1 (2020)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2019.1708066
Popis:	Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or with GM-CSF. Here we discuss the added value of GM-CSF and show sex-related differences.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/18a66b5567df494eaee6b3d2f17a3993 Zobrazit plný text záznamu View record in DOAJ