A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

Autor: Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C. Saido, Satoru Funamoto, Kiyotaka Nishikawa
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-023-04771-9
Popis: Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.
Databáze: Directory of Open Access Journals
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