Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19

Autor: Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Farhad Forouhar, Brandon Fowler, Seo Jung Hong, Hiroshi Mohri, Manoj S. Nair, Yaoxing Huang, Nicholas E. S. Tay, Sumin Lee, Charles Karan, Samuel J. Resnick, Colette Quinn, Wenjing Li, Henry Shion, Xin Xia, Jacob D. Daniels, Michelle Bartolo-Cruz, Marcelo Farina, Presha Rajbhandari, Christopher Jurtschenko, Matthew A. Lauber, Thomas McDonald, Michael E. Stokes, Brett L. Hurst, Tomislav Rovis, Alejandro Chavez, David D. Ho, Brent R. Stockwell
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29413-2
Popis: Small molecule drugs promise to remain a valuable tool in controlling the ongoing COVID-19 pandemic. Here the authors describe optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for potential treatment of COVID-19.
Databáze: Directory of Open Access Journals