| Autor: |
Pritesh Lalwani, Bárbara Batista Salgado, Ivanildo Vieira Pereira Filho, Danielle Severino Sena da Silva, Thiago Barros do Nascimento de Morais, Maele Ferreira Jordão, Aguyda Rayany Cavalcante Barbosa, Isabelle Bezerra Cordeiro, Júlio Nino de Souza Neto, Enedina Nogueira de Assunção, Rafaella Oliveira dos Santos, Nani Oliveira Carvalho, Wlademir Braga Salgado Sobrinho, Cristiano Fernandes da Costa, Pedro Elias de Souza, Bernardino Claudio de Albuquerque, Christian A. Ganoza, Roger V. Araujo-Castillo, Spartaco Astofi Filho, Jaila Dias Borges Lalwani |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 110, Iss , Pp 141-150 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2021.07.017 |
| Popis: |
ABSTRACT: Background: Manaus, located in the Brazilian rainforest, has experienced two health system collapses due to the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about which groups among the general population have been most affected. Methods: A convenience sampling strategy via online advertising recruited 3046 adults between 19 August 2020 and 2 October 2020. Sociodemographic characteristics, COVID-19-related symptoms, COVID-19 testing, self-medication and prescribed medications were recorded. Serum anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid immunoglobulin G antibodies were measured with an enzyme-linked immunosorbent assay. Prevalence ratios (PR) were obtained using cluster-corrected and adjusted Poisson's regression models. Results: A crude positivity rate among asymptomatic and symptomatic individuals was estimated at 29.10%, with maximum possible seroprevalence of 44.82% corrected by test characteristics and an antibody decay rate of 32.31%. Regression models demonstrated a strong association towards marginalized low-income and vulnerable residents with limited access to health care. The presence of a COVID-19 case [PR 1.39, 95% confidence interval (CI) 1.24–1.57] or death (PR 2.14, 95% CI 1.74–2.62) in a household greatly increased the risk of other household members acquiring infection. The seroprevalence of SARS-CoV-2 was higher among those who self-medicated to prevent infection (PR 1.36, 95% CI 1.27–1.46). Conclusions: Disproportionate socio-economic disparity was observed among the study participants. The syndemic nature of COVID-19 in the Amazon region needs differential policies and urgent solutions to control the ongoing pandemic. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
