Semiquantitative Assessment of Dishevelled-3 Phosphorylation Status by Mass Spectrometry

Autor: Hamáková Kateřina, Potěšil David, Bernatik Ondřej, Červenka Igor, Rádsetoulal Matěj, Bryja Vitězslav, Zdráhal Zbyněk
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Hungarian Journal of Industry and Chemistry, Vol 46, Iss 1, Pp 3-6 (2018)
Druh dokumentu: article
ISSN: 2450-5102
DOI: 10.1515/hjic-2018-0002
Popis: The focus of this paper is the human Dishevelled 3 protein (hDvl3), an essential component of the Wnt signalling pathway that contributes to their regulation. Mass spectrometry-based analysis of hDvl3 phosphorylations induced by eight associated kinases was performed revealing several dozens of phosphorylation sites. The main outcome of this study was the description of Dvl phosphorylation “patterns” induced by individual kinases
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