Fibrinogen dysfunction and fibrinolysis state in patients with hepatitis B-related cirrhosis

Autor: Yu Liu, Yan Zhuang, Guanqun Xu, Xuefeng Wang, Lanyi Lin, Qiulan Ding
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Hematology, Vol 29, Iss 1 (2024)
Druh dokumentu: article
ISSN: 16078454
1607-8454
DOI: 10.1080/16078454.2024.2392028
Popis: Objective To assess the fibrinogen function in patients with hepatitis B-related cirrhosis and explore the relationship between dysfibrinogenemia and bleeding and thrombotic events.Methods Medical records and laboratory data of the patients with hepatitis B-related cirrhosis were collected. Patients were categorized into three groups based on the Child-Pugh score. Fibrinogen activity and antigen, fibrinogen-bound sialic acid (FSA), fibrinogen polymerization and fibrinolysis kinetic analysis, thrombin-antithrombin complex (TAT) and plasmin-α2-antiplasmin complex (PAP) were detected.Results Eighty patients with seventeen, thirty-eight and twenty-five in Child-Pugh A, B and C, respectively, were included. Seventeen patients experienced bleeding events and eight patients had thrombotic events. Fibrinogen activity and antigen levels were reduced with the severity of cirrhosis. Twenty-two patients exhibited dysfibrinogenemia. The FSA levels in patients with non-dysfibrinogenemia and those with dysfibrinogenemia were increased to 1.25 and 1.37 times of healthy controls, negatively correlated with fibrinogen activity (ρ = −0.393, p = 0.006). Compared to healthy controls, the amount of clot formation was reduced (p
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