Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Autor: Jamie L. Endicott, Paula A. Nolte, Hui Shen, Peter W. Laird
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34268-8
Popis: DNA methylation loss has been observed in aging tissues and cancers for decades. Researchers from Van Andel Institute have now provided experimental evidence that this process is directly driven by cell division.
Databáze: Directory of Open Access Journals