| Autor: |
Jia-Chuan Lei, Cheng-Xiong Yang, Yuan Yang, Wu Zhang, Jian-Qing Yu |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 16, Iss , Pp 289-294 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2015.04.037 |
| Popis: |
Patrinia villosa Juss is a famous medicinal herb and is used as an anti-inflammatory and anti-bacterial agent. Its tender leaves have also been used as a wild vegetable in China. In this study, the antioxidant and cytotoxic activities of various fractions of ethanol extract from P. villosa were investigated, the ethyl acetate fraction (EE-PV) exhibited the strongest antioxidant activity and cytotoxic effect on four cancer cell lines. EE-PV also significantly inhibited the tumour growth in vivo. EE-PV was subjected to bioassay-guided isolation of active compounds by column chromatography. Phenolic compounds such as 5,7,4′-trihydroxy-3-methoxyflavone and p-hydroxybenzoic acid are mainly responsible for antioxidant activity. Ursolic acid as one of main constituents contributed to the antitumour activity of EE-PV. These results suggest that this plant extract could be considered as a potential source of functional food and pharmaceutical for preventing cancer and reducing the risk of chronic diseases associated with oxidative damage. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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