Elevated serum extracellular vesicle arginase 1 in type 2 diabetes mellitus: a cross-sectional study in middle-aged and elderly population

Autor: Xinwei Li, Wen Zhao, Lu Peng, Yu Li, Shaoping Nie, Huahui Yu, Yanwen Qin, Huina Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Endocrine Disorders, Vol 22, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1472-6823
DOI: 10.1186/s12902-022-00982-z
Popis: Abstract Background Serum extracellular vesicle (EV)-derived arginase 1 (ARG 1) plays a critical role in diabetes-associated endothelial dysfunction. This study was performed to determine the levels of serum EV-derived ARG 1 in T2DM and non-T2DM participants and to examine the association of serum EV-derived ARG 1 with T2DM incidence. Methods We performed a cross-sectional study in 103 Chinese, including 73 T2DM patients and 30 non-T2DM. Serum EVs were prepared via ultracentrifugation. Serum EV-derived ARG 1 levels were measured by enzyme-linked immunosorbent assay. The correlations between serum EV-derived ARG 1 and clinical variables were analyzed. The association of serum EV-derived ARG 1 levels with T2DM was determined by multivariate logistic regression analysis. Interaction subgroup analysis was used to evaluate the interaction of the relevant baselines on the association between serum EV-derived ARG 1 levels and T2DM. Results Serum EV-derived ARG 1 levels were significantly higher in T2DM patients compared with non-T2DM patients (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje