Nocturnal Hypoxia Activation of the Hedgehog Signaling Pathway Affects Pediatric Nonalcoholic Fatty Liver Disease Severity

Autor:	Shikha S. Sundaram, Marzena Swiderska‐Syn, Ronald J. Sokol, Ann C. Halbower, Kelley E. Capocelli, Zhaoxing Pan, Kristen Robbins, Brian Graham, Anna Mae Diehl
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Hepatology Communications, Vol 3, Iss 7, Pp 883-893 (2019)
Druh dokumentu:	article
ISSN:	2471-254X
DOI:	10.1002/hep4.1354
Popis:	Chronic intermittent hypoxia and hedgehog (Hh) pathway dysregulation are associated with nonalcoholic fatty liver disease (NAFLD) progression. In this study, we determined the relationship between obstructive sleep apnea (OSA)/nocturnal hypoxia and Hh signaling in pediatric NAFLD. Adolescents with histologic NAFLD (n = 31) underwent polysomnogram testing, laboratory testing, and Sonic Hh (SHh), Indian hedgehog (IHh), glioblastoma‐associated oncogene 2 (Gli2), keratin 7 (K7), α‐smooth muscle actin (α‐SMA), and hypoxia‐inducible factor 1α (HIF‐1α) immunohistochemistry. Aspartate aminotransferase (AST) correlated with SHh, r = 0.64; Gli2, r = 0.4; α‐SMA, r = 0.55; and K7, r = 0.45 (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d1840ce736084002a5ee66b931118c9b Zobrazit plný text záznamu Plný text View record in DOAJ