| Autor: |
Ana I. S. Esteves, Joao Goncalves, Madalena Humanes, Marisa Nicolai |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 9, Iss 1, Pp 139-153 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md9010139 |
| Popis: |
The extraction, fractionation and HIV-1 inhibition potential of polysaccharides extracted from three species of marine sponges, Erylus discophorus, Cliona celata and Stelletta sp., collected in the Northeastern Atlantic, is presented in this work. The anti-HIV activity of 23 polysaccharide pellets and three crude extracts was tested. Crude extracts prepared from Erylus discophorus specimens were all highly active against HIV-1 (90 to 95% inhibition). Cliona celata pellets showed low polysaccharide content (bellow 38.5%) and almost no anti-HIV activity (2000 kDa), whose mechanism is possibly preventing viral attachment and entry (fusion inhibitor). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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