Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study
| Autor: | Yan-mei Lou, Min-qi Liao, Chang-yi Wang, Hong-en Chen, Xiao-lin Peng, Xu-ping Gao, Shan Xu, Jian-ping Ma, Zhao Ping, Fang-fang Zeng |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2020-0013 2052-4897 |
| DOI: | 10.1136/bmjdrc-2020-001317 |
| Popis: | Introduction Brachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline ba-PWV value and new-onset T2DM among Chinese adults.Research design and methods Using data from Xiaotangshan Hospital, we conducted a prospective cohort study among those who underwent annual or biennial health check-up examinations and who had their ba-PWV measured from 2009 to 2016. We explored the risk of new-onset T2DM across ba-PWV tertiles using Cox proportional-hazards regression analysis.Results Of 6122 adults (68.9% male; mean age: 51.0 (SD 13.0) years) without T2DM and with ba-PWV measured at baseline, 599 participants developed T2DM during an average of 3.8 (SD 2.3) years of follow-up. After multivariable adjustment, ba-PWV was positively related to T2DM risk (p for trend=0.008). Compared with the lowest ba-PWV tertile, the HRs and their 95% CIs were 1.57 (1.18 to 2.10) for the second and 1.66 (1.24 to 2.22) for the third tertile. The risk across ba-PWV tertiles increased steadily from 1000 cm/s to 1400 cm/s and then reached a plateau. Subgroup analyses indicated a significantly higher risk among those aged |
| Databáze: | Directory of Open Access Journals |
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