Psychomotor activity and body weight gain after exposure to low ribavirin doses in rats: role of treatment duration

Autor: Petković Branka, Stojadinović Gordana, Kesić Srđan, Ristić Slavica, Martać Ljiljana, Podgorac Jelena, Pešić Vesna
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Archives of Biological Sciences, Vol 71, Iss 2, Pp 357-368 (2019)
Druh dokumentu: article
ISSN: 0354-4664
1821-4339
DOI: 10.2298/ABS190205018P
Popis: Clinically-related basic studies on the behavioral effects of ribavirin treatment are still lacking despite its wide use as an antiviral medication. This paper considers the effects of low ribavirin doses (10, 20 and 30 mg/kg/day) on psychomotor activity (novelty-induced exploratory behavior, d-amphetamine (AMPH, 1.5 mg/kg, intraperitoneal)-induced motor activity), and body weight gain in socially undisturbed adult male Wistar rats 24 h after the first, seventh and fourteenth once-a-day injection. Low doses of ribavirin were tested in an attempt to avoid the recognized systemic side effects related to high-dose usage. None of the singly applied ribavirin doses affected exploratory/spontaneous and AMPH-induced motor behavior (locomotion, stereotypy-like and vertical activity), however, body weight gain was significantly lower after treatment with 30 mg/kg of ribavirin. The 7- and 14-day treatments with 10 and 30 mg/kg/day of ribavirin significantly suppressed novelty-induced locomotion and body weight gain; the 14-day treatment with ribavirin at a dose of 30 mg/kg/ day decreased AMPH-induced stereotypy. These findings indicate that repeated application (up to 14 days) of low ribavirin doses results in low novelty-induced locomotion along with reduced weight gain, accentuating the existence of a U-shaped dose-response relationship with a prolonged duration of ribavirin treatment. [Projects of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173027 and Grant no. 173056]
Databáze: Directory of Open Access Journals
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