The role of creatine kinase in distinguishing generalized tonic–clonic seizures from psychogenic non-epileptic seizures (PNES) and syncope: a retrospective study and meta-analysis of 1300 patients

Autor: Ramy Abdelnaby, Anas Elgenidy, Jan Heckelmann, Mahmoud Mostafa Bedewy, Ahmed Samy Shabib, Mohamed Ayman Ebrahim, Khaled Abdelmoneim Elmenawi, Imene Maallem, Merna Wagih Youssef, Abdelrahman M. Attia, Mostafa Hossam Moawad, Khaled Ashraf Mohamed, Ahmed Gaballa
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Neurological Research and Practice, Vol 5, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 2524-3489
DOI: 10.1186/s42466-023-00286-0
Popis: Abstract Background/aim As the clinical differentiation between epileptic seizures, psychogenic non-epileptic seizures (PNES), and syncope depends mainly on a detailed report of the event, which may not be available, an objective assessment of a potential biochemical analysis is needed. We aimed to investigate whether serum creatine kinase (CK) could be used to differentiate epileptic seizure from PNES and syncope and to assess the strength of evidence present. Methods We directed a retrospective cohort study coupled with a systematic review and meta-analysis of studies that measured CK in patients with epilepsy, PNES, syncope, and healthy controls. Results The cohort study, which traced 202 patients, showed that the CK level was significantly higher 48 h after the event in the epilepsy group versus patients with syncope (p
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