| Autor: |
Lukas Pirpamer, Bálint Kincses, Zsigmond Tamás Kincses, Christian Kiss, Anna Damulina, Michael Khalil, Rudolf Stollberger, Reinhold Schmidt, Christian Enzinger, Stefan Ropele |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 34, Iss , Pp 103012- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2022.103012 |
| Popis: |
Objective: Recent studies suggested that CSF-mediated factors contribute to periventricular (PV) T2-hyperintense lesion formation in multiple sclerosis (MS) and this in turn correlates with cortical damage. We thus investigated if such PV-changes are observable microstructurally in early-MS and if they correlate with cortical damage. Methods: We assessed the magnetisation transfer ratio (MTR) in PV normal-appearing white matter (NAWM) and in MS lesions in 44 patients with a clinically isolated syndrome (CIS) suggestive of MS and 73 relapsing-remitting MS (RRMS) patients. Band-wise MTR values were related to cortical mean thickness (CMT) and compared with 49 healthy controls (HCs). For each band, MTR changes were assessed relative to the average MTR values of all HCs. Results: Relative to HCs, PV-MTR was significantly reduced up to 2.63% in CIS and 5.37% in RRMS (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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