The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China

Autor: Xiang Liu, Shengjia Shi, Jianhua Sun, Yuan He, Zhou Zhang, Junping Xing, Tie Chong
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Reproductive Health, Vol 20, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1742-4755
DOI: 10.1186/s12978-022-01558-9
Popis: Abstract Background Overweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This study aimed to assess the effects of both male and female body mass index (BMI), individually and in combination, on IVF outcomes. Methods This retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed. Results Regarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p 0.05). Conclusion Our findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences.
Databáze: Directory of Open Access Journals
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