Inflammatory bowel disease-specific findings are common morphological changes in the ileal pouch with ulcerative colitis

Autor: Kenichiro Toritani, Hideaki Kimura, Masako Otani, Hironori Fukuoka, Reiko Kunisaki, Jun Watanabe, Atsushi Ishibe, Toshihiro Misumi, Yoshiaki Inayama, Itaru Endo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-24708-2
Popis: Abstract Why inflammation is common in ileal pouches with ulcerative colitis (UC) is unclear. We therefore clarified the morphological changes in pouches and afferent limbs (AL) of patients with UC and explored the relationship between these findings. We evaluated the morphological findings (histological and endoscopic inflammation as the Pouchitis Disease Activity Index [PDAI] histology subscore [hPDAI] and endoscopy subscore [ePDAI], inflammatory bowel disease [IBD]-specific findings using the IBD score [SIBD], colonic metaplasia using the colonic metaplasia score [CMS], and goblet cell [GC] ratio) in the pouch and AL of patients with UC. A total of 261 pouchoscopies were analyzed. The pouch body had a higher hPDAI (p
Databáze: Directory of Open Access Journals
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