Assessment of influence of 'BESTFertil' supplement on semen analysis parameters, oxidative stress markers and sperm DNA fragmentation index in infertile males

Autor: S. I. Gamidov, A. Yu. Popova, N. G. Gasanov, R. I. Ovchinnikov, T. V. Shatylko
Jazyk: ruština
Rok vydání: 2019
Předmět:
Zdroj: Андрология и генитальная хирургия, Vol 20, Iss 1, Pp 91-98 (2019)
Druh dokumentu: article
ISSN: 2070-9781
DOI: 10.17650/2070-9781-2019-20-1-91-98
Popis: Background. Idiopathic male infertility remains an important problem in andrology and reproduction, despite steady advances in diagnostics and treatment of conditions associated with impaired fertility in men. Only available option of conservative treatment for idiopathic male infertility is an empiric antioxidant therapy.Materials and methods. Fifty five men from infertile couples without any identifiable cause of male infertility who received “BESTFertil” supplement were enrolled in this study. Semen analysis parameters (sperm density, percentage of sperm with progressive motility (categories A and B), sperm morphology, leukocyte concentration), MAR-test results, reactive oxygen species concentration as measured by chemiluminescence assay and sperm DNA fragmentation index evaluated using TUNEL method were registered and compared with baseline values after 90 days of treatment. Patient compliance was assessed by a number of capsules taken throughout the study period.Results. There was a significant difference in percentage of sperm with normal morphological features (median 2 % vs 4 %; p
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