Disparities in testicular cancer incidence, mortality, and place of death trends from 1999 to 2020: A comprehensive cohort study

Autor: Beck O. Gold, Anushka Ghosh, Saveli I. Goldberg, Fumiko Chino, Jason A. Efstathiou, Sophia C. Kamran
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cancer Reports, Vol 6, Iss 10, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2573-8348
DOI: 10.1002/cnr2.1880
Popis: Abstract Background Testicular cancer (TC) mortality rates have decreased over time, however it is unclear whether these improvements are consistent across all communities. Aims The aim of this study was to analyze trends in TC incidence, mortality, and place of death (PoD) in the United States between 1999–2020 and identify disparities across race, ethnicity, and geographic location. Methods and Results This cross‐sectional study used CDC WONDER and NAACCR, to calculate age‐adjusted rates of TC incidence and mortality, respectively. PoD data for individuals who died of TC were collected from CDC WONDER. Using Joinpoint analysis, longitudinal mortality trends were evaluated by age, race, ethnicity, US census region, and urbanization category. TC stage (localized vs metastatic) trends were also evaluated. Univariate and multivariate regression analysis identified demographic disparities for PoD. A total of 8,456 patients died of TC from 1999–2020. Average annual percent change (AAPC) of testicular cancer‐specific mortality (TCSM) remained largely stable (AAPC, 0.4; 95% CI −0.2 to 0.9; p = 0.215). Men ages 25–29 experienced a significant increase in TCSM (AAPC, 1.3, p = 0.003), consistent with increased metastatic testicular cancer‐specific incidence (TCSI) trend for this age group (AAPC, 1.6; p
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