OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR

Autor: Xuhong Fu, Junjie Zhao, Guopeng Yu, Xiaomin Zhang, Jie Sun, Lingmeng Li, Jingyi Yin, Yinan Niu, Shancheng Ren, Yasheng Zhu, Bin Xu, Liyu Huang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03133-1
Popis: OTUD6A, a deubiquitinase, is amplified in prostate cancer and correlates with poor survivability, increasing the growth of prostate cancer cell lines and PDX models. OTUD6A stabilizes the expression of Brg1 and AR through the removal of K27- and K11-linked polyubiquination.
Databáze: Directory of Open Access Journals
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