Enterovirus genotype diversity with emergence of coxsackievirus A2 circulating in pediatric patients with acute gastroenteritis in Thailand, 2019–2022

Autor: Zhenfeng Xie, Pattara Khamrin, Nutthawadee Jampanil, Arpaporn Yodmeeklin, Nuthapong Ukarapol, Niwat Maneekarn, Kattareeya Kumthip
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Microbiology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-302X
DOI: 10.3389/fmicb.2024.1414698
Popis: IntroductionEnteroviruses (EVs) are recognized as potential causative agents of acute gastroenteritis (AGE) in children worldwide. This study aimed to investigate the epidemiology and molecular characteristics of EV infection in children admitted to hospitals with AGE in Chiang Mai, Thailand from 2019 to 2022.MethodsA total of 1,148 fecal samples collected from patients with AGE were screened for the presence of EV using RT-PCR. The prevalence, co-infection with common diarrheal viruses, and seasonal pattern of EV were examined. The genotypes of EV were identified based on the VP1 sequence and phylogenetic analysis.ResultsThe overall prevalence of EV in AGE patients was 8.8% (101/1,148). After the COVID-19 outbreak in 2019, a significant decrease in the EV infection rate and genotype diversity was observed (p
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